Posts Tagged ‘In vitro fertilisation’

IVF with multiple births leads to small increased risk of mental retardation

July 3, 2013

A new paper describing a Swedish study:

Sandin S et al. Autism and mental retardation among offspring born after in vitro fertilization. JAMA 2013 Jul 3; 310:75. (http://dx.doi.org/10.1001/jama.2013.7222)

NewswiseIn a study that included more than 2.5 million children born in Sweden, compared with spontaneous conception, any in vitro fertilization (IVF) treatment was not associated with autistic disorder but was associated with a small but statistically significantly increased risk of mental retardation, according to a study in the July 3 issue of JAMA. The authors note that the prevalence of these disorders was low, and the increase in absolute risk associated with IVF was small. …..

…… A total of 2,541,125 children were alive at 1.5 years of age and had complete data on all the covariates; 30,959 (1.2 percent) were born following an IVF procedure. Autistic disorder was diagnosed in 103 of 6,959 children (1.5 percent) and mental retardation in 180 of 15,830 children (1.1 percent) who were born after an IVF procedure. Cases had an average follow-up time of 10 years, median (midpoint) 14 years.

Analysis of the data indicated that compared with spontaneous conception, any IVF treatment was not associated with autistic disorder but was associated with a small but statistically significantly increased risk of mental retardation, although when restricted to singletons (single births), the risk for mental retardation was no longer statistically significant. “However, the results demonstrated an association between autistic disorder and mental retardation and specific IVF procedures with ICSI related to paternal origin of infertility compared with IVF without ICSI,” the authors write.

“The prevalence of these disorders was low, and the increase in absolute risk associated with IVF was small. These associations should be assessed in other populations.”

 

 

Medicine Nobel to Robert Edwards for IVF

October 4, 2010
SvD: Thirteen minutes before midnight on July 25, 1978 Louise Joy Brown delivered a baby girl by Caesarean section at Oldham General Hospital outside Manchester UK.
The girl weighed 2610 grams and the responsible physician Patrick Steptoe was soon able to reassure the hundreds of journalists gathered that “all studies have shown that the child is completely normal. ” The news of the birth was a medical sensation. Louise Brown was the first child in the world born with the aid of in vitro fertilisation (IVF).

BBC: Robert Edwards, the man who devised the fertility treatment IVF, has been awarded this year’s Nobel prize for medicine. His efforts in the 1950s, 60s and 70s led to the birth of the world’s first “test tube baby” in July 1978. Since then more than four million babies have been born following IVF.

The prize committee said his achievements had made it possible to treat infertility, a medical condition affecting 10% of all couples worldwide.

(That’s one prediction I got wrong)


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