Posts Tagged ‘Scientific misconduct’

Erasmus University, Rotterdam sacks Professor of cardio-vascular medicine for scientific misconduct

November 17, 2011
Don Poldermans

Don Poldermans

Universities in Holland are having a torrid time with another dismissal for scientific misconduct, this time at Erasmus University in Rotterdam. But the seriousness with which investigations are carried out and the speed and decisiveness with which Dutch Universities act is quite impressive.

Professor Don Poldermans, MD, PhD, is was  Professor of Medicine and head of the section perioperative cardiac care of the Erasmus Medical Centre, Rotterdam, the Netherlands. Dr Poldermans received his medical degree at the Erasmus Medical Centre in 1981. He is a fellow of the European Society of Cardiology and an honorary member of the Dutch Society of Anesthesiology. He is active within the Departments of Anesthesiology, Internal Medicine, and Surgery of the Erasmus Medical Centre, Rotterdam, the Netherlands.

Dr Poldermans is actively involved in patient care, education, research, and administration. He supervised 26 PhD students, all working on cardiovascular research. He has published more than 600 manuscripts in several peer-reviewed Journals, including the New England Journal of Medicine, Lancet, JAMA, Circulation, and the Journal of the American College of Cardiology.

Dutch News:

Erasmus University in Rotterdam has sacked a professor in cardio-vascular medicine for damaging the institution’s academic integrity and for ‘scientific misconduct’, the NRC  reports on Thursday.

The professor is accused of faking academic data and compromising patient trust, the paper says. In particular, he failed to obtain patient consent for carrying out research and recorded results ‘which cannot be resolved to patient information,’ the university said.

Don Poldermans has spent years researching the risk of complications during cardio-vascular surgery and has some 500 publications to his name.

A spokesman for Poldermans told the paper he admitted not keeping to research protocols but denied faking data.

Last month, Tilburg and Groningen universities said they planned to take legal action against behavioural science professor Diederik Stapel after an investigation showed he had faked research data in at least 30 scientific papers.

According to Elsevier, an investigation committee brought the fraud to light. It found that Poldermans had taken blood samples and heart echoes from patients without their permisssion and has reported results which cannot be traced to any patient.
“Patients were not physically harmed,” emphasizes Dean and Director Huib Pols. He said he was deeply shocked by the case. Patients who participated in the latest survey receive a letter of apology from the hospital.
Related: Diedrik Stapel faked at least 30 papers

National University of Singapore exonerates Yoshiaki Ito of misconduct

November 15, 2011

Not entirely unexpected that Yoshiaki Ito would be exonerated by the National University of Singapore but the speed of the investigation and the exoneration is noteworthy.

ScienceInsider:

The National University of Singapore (NUS) announced today that it has found no evidence of research misconduct by Yoshiaki Ito, a high-profile cancer researcher accused of data fabrication. However, the finding does not resolve the underlying—and long-running—scientific dispute over whether a gene known as Runx3 is a tumor suppressor.

(more…)

University of Virginia physician found to have plagiarised 5 papers and sentenced to be supervised for 4 years

November 7, 2011

The US Office of Research Integrity has now made a finding of research misconduct in the case of Jayant Jagannathan and has applied sanctions for a period of 4 years.

Jagannathan was a former resident physician at the University of Virginia Medical Center and was found to have committed plagiarism in research supported by the National Institutes of Health and published in 5 papers between 2005 and 2009:

(more…)

Investigations of misconduct at Singapore need to be seen to be impartial

November 7, 2011

The saga of potential misconduct at the National University of Singapore continues to escalate with further questionable papers regularly being identified by “whistleblowers” to Abnormal Science (Joerg Zwirner).

But the investigations initiated by the University are not totally above criticism especially as Prof. Barry Haliwell the Vice President at the University and responsible for these investigations is himself facing allegations of self-plagiarism and is a co-author on some of the questionable papers. There is an urgent need for some outside participation in the investigations to ensure independence and impartiality. My current perception is that the objective of the investigation will over-ridingly be to save the reputation of the University (any by extension of the government of Singapore) and that the investigation committee will be heavily blinkered. Since the government has effectively been trying to short-cut its way to a scientific reputation by “buying in” researchers, there is little chance that the investigations – as they are set up now – will not be contaminated by government meddling.

As Abnormal Science comments:

A more stringent management of quality and integrity issues in experimental (medical ) research needs to take center stage at NUS. Vice president Prof. Halliwell  is in charge of the Office of Research and Technology at NUS,  and therefore responsible for driving the University’s research agenda. Unfortunately, he also appears to handle issues related to science integrity at NUS himself. This constellation constitutes an inacceptable accumulation of responsibilities and should be banned since it carries the potential for conflict of interest. Prof. Halliwell, you might want to take a leave of absence from your position as vice president until these issues (including the allegation of self-plagiarism) have been resolved.

More dodgy papers for National University of Singapore to investigate

October 24, 2011

Update: 31st October 2011: Further dodgy papers are given in the next instalment from Abnormal Science.

Japanese Retraction Watch has also been on the case.

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Abnormal Science ( Joerg Zwirner) has 3 more examples of papers with some questionable images. This time the papers are from the Department of Physiology, National University of Singapore with 2 papers published in Blood and one in the Journal of Biological Chemistry.

The three papers tagged are:

1. Pervaiz S, Seyed MA, Hirpara JL, Clément MV, Loh KW.
Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells.
Blood. 1999 Jun 15;93(12):4096-108.
Department of Physiology, National University of Singapore; and the Oncology Research Institute, NUMI, Singapore

2. Hirpara JL, Seyed MA, Loh KW, Dong H, Kini RM, Pervaiz S.
Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells.
Blood. 2000 Mar 1;95(5):1773-80.
Department of Physiology, National University of Singapore, Singapore.

3. Hirpara JL, Clément MV, Pervaiz S.
Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells.
J Biol Chem. 2001 Jan 5;276(1):514-21.
Department of Physiology, National University of Singapore, Singapore

The two names common to all 3 papers are JL Hirpara and research supervisor Professor Shazib Pervaiz.

The NUS investigation committee has its work cut out with all the questionable papers they need to check out (See here and here).

As Abnormal Science puts it:

Their inquiry commissions might soon run out of unbiased members. NUS should consider to accept assistance from abroad to clean up the mess.

And it seems to be truly a mess covering a number of departments which indicates a prevailing culture and not just some isolated incident of wrongdoing.

Scientific retractions increasing sharply but is it due to better detection or increased misconduct?

October 5, 2011

Retractions of scientific papers is increasing sharply.

I am a strong believer in the Rule of the Iceberg where “whatever becomes visible is only 10% of all that exists”. And while I do not know if the number of retractions of scientific papers is increasing because detection methods are improved or because scientific misconduct is increasing, I am quite sure that the misconduct that is indicated by retractions is only a small part of all the misconduct that goes on.

What is clear however is that the world wide web provides a powerful new forum for the exercising of a check and a balance. It provides a hitherto unavailable method for mobilising resources from a wide and disparate group of individuals. The success of web sites such as Retraction Watch and Vroniplag are testimony to this. And the investigative power of the on-line community is particularly evident with Vroniplag as has been described by Prof.  Debora Weber-Wulff’s blog. And this investigative power – even if made up of “amateurs” in the on-line community – can bring to bear a vast and varying experience of techniques and expertise which – if harnessed towards a particular target – can function extremely rapidly. The recent on-line investigation and disclosure that an award winning nature photographer had been photo-shopping a great number of photographs of lynxes, wolves and raccoons and had invented stories about his encounters was entirely due to “amateurs” on the Flashback Forum in Sweden who very quickly created a web site to disclose all his trangressions and exactly how he had manipulated his images.

Nature addresses the subject of retractions today:

This week, some 27,000 freshly published research articles will pour into the Web of Science, Thomson Reuters’ vast online database of scientific publications. Almost all of these papers will stay there forever, a fixed contribution to the research literature. But 200 or so will eventually be flagged with a note of alteration such as a correction. And a handful — maybe five or six — will one day receive science’s ultimate post-publication punishment: retraction, the official declaration that a paper is so flawed that it must be withdrawn from the literature. … But retraction notices are increasing rapidly. In the early 2000s, only about 30 retraction notices appeared annually. This year, the Web of Science is on track to index more than 400 (see ‘Rise of the retractions’) — even though the total number of papers published has risen by only 44% over the past decade. …. 

…… When the UK-based Committee on Publication Ethics (COPE) surveyed editors’ attitudes to retraction two years ago, it found huge inconsistencies in policies and practices between journals, says Elizabeth Wager, a medical writer in Princes Risborough, UK, who is chair of COPE. That survey led to retraction guidelines that COPE published in 2009. But it’s still the case, says Wager, that “editors often have to be pushed to retract”. …… 

In surveys, around 1–2% of scientists admit to having fabricated, falsified or modified data or results at least once (D. Fanelli PLoS ONE4, e5738; 2009). But over the past decade, retraction notices for published papers have increased from 0.001% of the total to only about 0.02%. And, Ioannidis says, that subset of papers is “the tip of the iceberg” — too small and fragmentary for any useful conclusions to be drawn about the overall rates of sloppiness or misconduct.

Instead, it is more probable that the growth in retractions has come from an increased awareness of research misconduct, says Steneck. That’s thanks in part to the setting up of regulatory bodies such as the US Office of Research Integrity in the Department of Health and Human Services. These ensure greater accountability for the research institutions, which, along with researchers, are responsible for detecting mistakes.

The growth also owes a lot to the emergence of software for easily detecting plagiarism and image manipulation, combined with the greater number of readers that the Internet brings to research papers. In the future, wider use of such software could cause the rate of retraction notices to dip as fast as it spiked, simply because more of the problematic papers will be screened out before they reach publication. On the other hand, editors’ newfound comfort with talking about retraction may lead to notices coming at an even greater rate. …… 

Read the article

A graphic of retractions is here.

The academic and scientific community will – perforce – mirror the surrounding society it is embedded in. Standards of ethics and instances of misconduct will follow those of the surrounding environment. But the scientific community is somewhat protected in terms of not often having to bear liability for what they have published. Having to bear some responsibility and face liability for the quality of what they produce can be a force which will improve ethical standards immensely. Bringing incompetent or cheating scientists to book is not an attack on science. And it is what science needs to regain some of the reputation that has been tarnished in recent times. With the spotlight that is now available in the form of the world wide web, I expect the level of scrutiny to increase and this too can only be a force for the good.

Scientific negligence goes on trial for manslaughter in Italy

September 20, 2011

“Scientists” today enjoy a general reputation for being unbiased, objective, incorruptible and dauntless seekers after truth. With this reputation they also have little liability for their pronouncements or for the integrity or the quality of their work. This is not sustainable as the politicisation of science is increasingly unavoidable and temptations for scientific misconduct grow. To try and de-politicise science is impractical. More emphasis can be placed on developing ethical standards which should reduce the incidence of misconduct. But I think the key is to ensure that scientists carry some liability for what they do and that they do it honestly. A scientist is no less a professional than a lawyer or an engineer or a physician or an architect. They do have some liability for the quality of what they do. Incompetence, negligence or dishonesty carry penalties for other professions and scientists can not and should not be exempt.

Of course the scientific community is up in arms about the seismologists being tried for manslaughter in Italy, but they do need to be held accountable for their negligence or incompetence – if demonstrated. Wearing a white coat and calling oneself a “scientist” should not provide automatic immunity from accountability and liability.

Scientific American:  By Nicola Nosengo

Six Italian seismologists and one government official will be tried for the manslaughter of those who died in the earthquake that struck the city of L’Aquila on 6 April 2009. The seven were on a committee that had been tasked with assessing the risk associated with recent increases in seismic activity in the area. Following a committee meeting just a week before the quake, some members of the group assured the public that they were in no danger. 

In the aftermath of the quake, which killed 309 people, many citizens said that these reassurances were the reason they did not take precautionary measures, such as leaving their homes. As a consequence, the public prosecutor of L’Aquila pressed manslaughter charges against all the participants in the meeting, on the grounds that they had falsely reassured the public. After several delays, the public prosecutor Fabio Picuti and the defendants’ lawyers appeared this week before Giuseppe Gargarella, the judge for preliminary hearings, who had to decide whether to dismiss the case or proceed with a trial.

During the hearing, the prosecutor called the committee’s risk assessment “superficial and generic”, resulting in “incomplete, imprecise and contradictory public information”. Responding to the thousands of scientists who had signed a letter of support for the defendants, the prosecutor acknowledged that the committee members had no way of predicting the earthquake, but he accused them of translating their scientific uncertainty into an overly optimistic message. More specifically, the accusation focuses on a statement made at a press conference on 31 March 2009 by Bernardo De Bernardinis, who was then deputy technical head of Italy’s Civil Protection Agency and is now president of the Institute for Environmental Protection and Research in Rome. “The scientific community tells me there is no danger,” he said, “because there is an ongoing discharge of energy. The situation looks favorable”. ….

 At the end of the hearing, the judge decided that the trial will begin on 20 September. …

The earthquake was surely not predictable and poor building standards surely contributed to the deaths but whether the scientists exhibited incompetence or negligence is a valid question. And if they did they need to be held accountable even if not perhaps for manslaughter.

Tilburg University on terms of reference for Diederik Stapel misconduct inquiry

September 15, 2011

Following the suspension (pending dismissal) of Diederik Stapel for faking data, Tilburg University has published the terms of reference of the Levelt investigation committee and which is to report latest by the end of October.

Universiteit van Tilburg

Rector Magnificus of Tilburg University Prof. P. Eijlander has asked the Levelt Committee to investigate the extent and nature of the breach of scientific integrity committed by mr. Stapel. There are two elements to the task:

  1. The committee will examine which publications are based on fictitious data or fictitious scientific studies and during which period the misconduct took place.
  2. The committee should form a view on the methods and the research culture that facilitated this breach of scientific integrity, and make recommendations on how to prevent any recurrence of this.

The committee will publish its (interim) report by the end of October at the latest. The universities of Groningen and Amsterdam have both appointed staff members responsible for communication with the inquiry. 

Members committee
Prof.dr. W.J.M. Levelt, Prof.mr. M.S. Groenhuijsen, Prof.dr. J.A.P. Hagenaars,

Dr.ir. S.A.M. Baert (secretary)

Prof. Levelt is a psycho-linguist and former president of the Royal Netherlands Academy of Arts and Sciences while Prof. Groenhuijsen and Prof. Hagenaars are from Tilburg’s Law School.

Stapel has agreed to cooperate fully with the investigation and to help identify every instance of data fabrication. There are likely to be a number of retractions to come from among his published papers. It would though be a good sign if the Journals involved were to be pro-active in identifying these rather than starting their processes only after the investigation was complete. Some of the journals involved could be ScienceEuropean Journal of Social Psychology, Journal of Personality and Social Psychology and Journal of Experimental Social Psychology.

Political goals distort the science done by the US National Parks Service

September 13, 2011

This is not the first time of course that slanted and pre-determined conclusions to suit a political agenda are drawn from supposedly “rigorously peer-reviewed research”. Peer-review carried out correctly is no doubt very effective but it also always discourages the non-establishment view. And if the establishment has a preconceived “belief”, then any views dissenting from that orthodoxy are easy to suppress.

ABC reports:

There are new allegations of scientific misconduct being directed at the National Park Service. A park service study claims an oyster farm in the Point Reyes National Seashore is harming wildlife, but there are disturbing new questions about the science behind that study. 

The Drakes Bay Oyster Company has been at Point Reyes since the 1930s, but the National Park Service says it must close in 2012 in order to return it back to wilderness. The park service released a study in April claiming to have evidence the oyster farm is a threat to harbor seals, driving them out of their home in Drakes Estero. However, an independent analysis by outside experts shows that evidence is slanted to make the oyster farm look bad.

Addendum (21st September 2011)

It seems (not yet confirmed) that the paper in question is Modeling the effects of El Nino, density-dependence,and disturbance on harbor seal (Phoca vitulina) counts in Drakes Estero, California: 1997–2007 by Becker, Press and Allen,
MARINE MAMMAL SCIENCE, 25(1): 1–18 ( January 2009), Society for Marine Mammalogy, DOI: 10.1111/j.1748-7692.2008.00234.x

I think the problematic paragraph could be this one in the Results section
Disturbance rates in the upper estero (subsites OB, UEF, UEN) significantly
increased with oyster harvest (rs = 0.55, P < 0.03) (Fig. 2B). This correlation
is highly robust to sample size. For example, there was still a significant positive
correlation (rs = 0.53, P < 0.04) of disturbance rate with oyster harvest even
when removing the 2006 disturbance, four of the 2007 disturbances (including two
disturbances on 1 day in 2007 that the mariculture company challenged), and four of
the 1996 disturbances (nine total) from the analysis. Similarly, oyster harvest levels
in years with oyster related disturbances were significantly higher (U = 43, n =
13, P1−tail < 0.04). 

The independent study itself seems to have been done by heavyweights in the world of science led by Corey S Goodman:

“This is a published paper, it’s publicly available, it’s been supported by taxpayer dollars, it’s done by government scientists,” said biologist Corey Goodman, Ph.D. Goodman is a member of the National Academy of Sciences and he has published more than 200 scientific papers. He was asked by a Marin County supervisor in 2007 to look into how the park was conducting scientific research and he’s been pouring over data ever since. ……. 

It took the National Park Service three months to hand over their data to Goodman. When he finally got it, he shared it with statisticians at Stanford and U.C. Davis to see if they could replicate the results. “And what I find is that none of the conclusions in the paper are valid,” said Goodman. ……That’s why Goodman is charging the park service with distorting science to fit their ultimate goal of closing the oyster farm. 

Further details of Dr. Goodman’s charges of scientific misconduct are here.

The author of the Parks Service paper seems to have gone into hiding and the Parks Service is in a defensive mode.

ABC7 wanted to hear from the park service scientist who wrote the study, Dr. Ben Becker, director of the Pacific Coast Science and Learning Center at Point Reyes National Seashore. We asked the park service for an interview, left messages for Becker, and sent emails, but never heard back. We even went to his house to get answers, but Becker refused to answer our questions.

Park service spokesman Melanie Gunn told us in an email that Becker’s paper “went through a rigorous peer review process.”

But merely invoking peer-review -which is notoriously patchy in its quality – and which often ends up as being “pal-review” is unlikely to be enough in this case.

Goodman’s concerns were still enough to raise the interest of Sen. Dianne Feinstein, D-California. The senator has asked the Marine Mammal Commission to do an independent review of the park service study and now she wants the park service to delay its environmental impact statement on the oyster farm until after that review. She sent a letter to Interior Secretary Ken Salazar.

In it the letter, Feinstein says: “I fear that if the Department of Interior does not stand behind the independent analysis, it will be another example of a lack of credibility at Point Reyes National Seashore.”

The park service says it is cooperating with the review but still plans to release its report this month, adding that “Dr. Becker continues to work with the Marine Mammal Commission on any remaining questions the Commission may have.”

Related: Peer review and the corruption of science

Sangiliyandi Gurunathan on his way to another private University in South India

September 5, 2011

Kalasalingam University recently took strong action against a Professor and 6 PhD students for scientific misconduct which included data manipulation and plagiarism. Dr. G Sangliyandi, Senior Professor and Head, Department of Biotechnology, and Dean, International Relations, Kalasalingam University was directed to resign from the University. The 6 PhD students involved had their registrations cancelled.

His name has been removed from the Department of Biotechnology page at the university website but still appeared on the International Relations page last week.

It seems that Dr. Gurunathan has been offered (and is said to have accepted) a position at another private University in Southern India – also at a Department of Bio-technology but it has not been possible to confirm this. 

One reader comments that all the six students involved are still continuing at Kalasalingam University

All the 6 research scholars, whose Ph.D registration has been cancelled are still doing (continuing) their research work in the department itself on the support of Prof. Dr. K. Sundar.

If this is true then it seems that Sangiliyandi Gurunathan is being assigned all the blame for the wrong-doings at his lab and not primarily the students he had initially blamed. Presumably the students have new PhD registrations and stern warnings about maintaining good conduct and about the ethics of plagiarism and image manipulation!